Nataliya Karyakina, MD, PhD

Health Risk Analyst

Nataliya Karyakina is a toxicologist and health risk analyst at Risk Sciences International and at McLaughlin Centre for Population Health Risk Assessment Institute of Population Health at the University of Ottawa.  Her academic background includes a Bachelor degree in Medicine, a Master’s Degree in Epidemiology, and Ph.D. in Toxicology.

Nataliya’s research has a particular focus on multidisciplinary studies regarding the adverse effects  (cancer, mutations, endocrine disruption, neurotoxicity and toxicity to reproduction, etc.) of pharmaceuticals, including vaccines, and endocrine disruption compounds in general population following oral intake, inhalation and dermal exposure; environmental fate and toxicokinetic of the hazardous chemicals, essential and toxic metals, endocrine active chemicals and drugs with different mode of actions (aluminium, manganese, bisphenol A, estradiol, ethinyl estradiol, conjugated estrogens, phytoestrogens); research and derivation of the biomonitoring  equivalents of toxic metals (e.g., lithium, tellurium, titanium dioxide, lanthanum); development of adverse outcome pathways for evaluation of carcinogenic potential of poorly soluble low toxic metals and it oxides (TiO2, Al2O3); research and development of toxicity profiles for chemicals on Health Canada’s Domestic Substances List (DSL) (Carbon Black, phthalates, brominated flame retardants); evaluation of hazardous properties, classification and labeling  of toxic chemical compounds in according to CLP (EC) 1272/2008 for European Union REACH program (aluminium, manganese, cooper); derivation of health-based Derived No Effect Levels (DNELs) for workers and general population; considerations regarding safety of new drugs presented in the environment and occupational settings.

Nataliya has solid experience working on human health hazard and risk assessment of pesticide’s residues in soil and food products; development of health-based regulatory guidance and values of hazardous chemicals in different types of soil, surface and groundwater water used as a source of drinking water consumption, and food products. She has been involved in detailed review of toxicological data for a new veterinary drug; systematic review of carcinogenic hazard associated with a perineal use of talc by general population; she conducted a systematic review of potential health risks associated with insoluble and soluble aluminum compounds, which has been published in Critical Reviews in Toxicology,  pharmaco- and toxicokinetic of selected exogenous and endogenous estrogens, which has been published  in Critical Reviews in Toxicology, a comprehensive review of the literature related to the human health effects of manganese and severity scoring of neurotoxic outcomes following inhalation exposure to manganese which has been published in the journal of Neurotoxicology; an overviews of the derivation of DNEL values based on REACH guidance is prepared for a publication in the journal of Neurotoxicology.