Selected Publications by RSI Staff


Davidson, Melissa & Mattison, Donald & Azoulay, Laurent & Krewski, Daniel. Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future. Critical Reviews in Toxicology. 2017 August

Gurusankar, Roma & Yenugadhati, Nagarajkumar & Krishnan, Kannan & Mattison, Donald & Krewski, Daniel et al. The role of human biological monitoring in health risk assessment. International Journal of Risk Assessment and Management.  2017

Krewski, Daniel & Barakat-Haddad, Caroline & Donnan, Jennifer & Martino, Rosemary & Pringsheim, Tamara et al.  Determinants of neurological disease: Synthesis of systematic reviews.  Neurotoxicology 2017 Apr 1


Cheng VYS, Arhonditsis GB, Sills DML, Gough WA, Auld H. Predicting the Climatology of Tornado Occurrences in North America with a Bayesian Hierarchical Modeling Framework. Journal of Climate 2016;29:1899-917.

Gaskin J, Gomes J, Darshan S, Krewski D. Burden of neurological conditions in Canada. Neurotoxicology 2016 May 3.

Mattison DR. Computational methods for reproductive and developmental toxicology.  CRC Press, Taylor & Francis Group; 2016.

Milton B, Farrell PJ, Birkett N, Krewski D. Modeling U-Shaped Exposure-Response Relationships for Agents that Demonstrate Toxicity Due to Both Excess and Deficiency. Risk Anal 2016 Apr 4.

Milton B, Krewski D, Mattison DR, Karyakina NA, Ramoju S, Shilnikova N, et al. Modeling U-shaped dose-response curves for manganese using categorical regression. Neurotoxicology 2016 Oct 5.

Oraby T, Al-Zoughool M, Elsaadany S, Krewski D. A stochastic model of the bovine spongiform encephalopathy epidemic in Canada. J Toxicol Environ Health A 2016;79(16-17):677-89.

Poddalgoda D, Macey K, Jayawardene I, Krishnan K. Derivation of biomonitoring equivalent for inorganic tin for interpreting population-level urinary biomonitoring data. Regul Toxicol Pharmacol 2016 Nov;81:430-6.

Sand S, Parham F, Portier CJ, Tice RR, Krewski D. Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data. Environ Health Perspect 2016 Jul 6.

Wang MD, Little J, Gomes J, Cashman NR, Krewski D. Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. Neurotoxicology 2016 Jul 1.


Andersen ME, McMullen PD, Krewski D. Developing tools for defining and establishing pathways of toxicity. Arch Toxicol 2015 May;89(5):809-12.

Cheng VY, Arhonditsis GB, Sills DM, Gough WA, Auld H. A Bayesian modelling framework for tornado occurrences in North America. Nat Commun 2015 Mar 25;6:6599.

Crispo JA, Fortin Y, Thibault DP, Emons M, Bjerre LM, Kohen DE, et al. Trends in inpatient antiparkinson drug use in the USA, 2001-2012. Eur J Clin Pharmacol 2015 Aug;71(8):1011-9.

Crispo JA, Fortin Y, Sikora L, Kohen DE, Bjerre LM, Mattison DR, et al. Non-ergot dopamine agonists and the risk of heart failure and other adverse cardiovascular reactions in Parkinson’s disease (protocol). Cochrane Database of Systematic Reviews 2015.

Ford JD, Champalle C, Tudge P, Riedlsperger R, Bell T, Sparling E. Evaluating climate change vulnerability assessments: a case study of research focusing on the built environment in northern Canada. Mitigation and Adaptation Strategies for Global Change 2015;20(8):1267-88.

Hamel S, McNair DS, Birkett NJ, Mattison DR, Krantis A, Krewski D. Off-label use of cancer therapies in women diagnosed with breast cancer in the United States. Springerplus 2015;4:209.

LaKind JS, Goodman M, Makris SL, Mattison DR. Improving Concordance in Environmental Epidemiology: A Three-Part Proposal. J Toxicol Environ Health B Crit Rev 2015;18(2):105-20.

Pope CA, III, Turner MC, Burnett RT, Jerrett M, Gapstur SM, Diver WR, et al. Relationships between fine particulate air pollution, cardiometabolic disorders, and cardiovascular mortality. Circ Res 2015 Jan 2;116(1):108-15.

Smith BA, Ruthman T, Sparling E, Auld H, Comer N, Young I, et al. A risk modeling framework to evaluate the impacts of climate change and adaptation on food and water safety. Food Research International 2015;68:78-85.


Bessems JG, Loizou G, Krishnan K, Clewell HJ, III, Bernasconi C, Bois F, et al. PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA–EURL ECVAM ADME workshop. Regul Toxicol Pharmacol 2014 Feb;68(1):119-39. 6

Goodman M, LaKind JS, Mattison DR. Do phthalates act as obesogens in humans? A systematic review of the epidemiological literature. Crit Rev Toxicol 2014 Feb;44(2):151-75.

Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, et al. A framework for the next generation of risk science. Environ Health Perspect 2014 Aug;122(8):796-805.

LaKind JS, Goodman M, Mattison DR. Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: a systematic review of epidemiologic research. Crit Rev Toxicol 2014 Feb;44(2):121-50.

Mattison DR, Karyakina N, Goodman M, LaKind JS. Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: a review of the data and identification of knowledge gaps. Crit Rev Toxicol 2014 Sep;44(8):696-724.

Moore TJ, Cohen MR, Mattison DR. Dabigatran, bleeding, and the regulators. BMJ 2014 Jul 23;349:g4517.

Moore TJ, Glenmullen J, Mattison DR. Reports of pathological gambling, hypersexuality, and compulsive shopping associated with dopamine receptor agonist drugs. JAMA Intern Med 2014 Dec;174(12):1930-3.

Rogers C, Eng S, Sparling E, Douglas A, Byer P, Auld H. Assessing the Treatment of Climate Change Impacts and Adaptation in Project Level EAs in the Canadian Mining Sector, report submitted to Climate Change Impacts and Adaptation Division, Natural Resources Canada.  2014.

Willhite CC, Karyakina NA, Yokel RA, Yenugadhati N, Wisniewski TM, Arnold IM, et al. Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts. Crit Rev Toxicol 2014 Oct;44 Suppl 4:1-80.

Zhuo L, Farrell PJ, McNair D, Krewski D. Statistical methods for active pharmacovigilance, with applications to diabetes drugs. J Biopharm Stat 2014;24(4):856-73.


Canady R, Lane R, Paoli G, Wilson M, Bialk H, Hermansky S, et al. Determining the applicability of threshold of toxicological concern approaches to substances found in foods. Crit Rev Food Sci Nutr 2013;53(12):1239-49.

Chen Y, Dennis SB, Hartnett E, Paoli G, Pouillot R, Ruthman T, et al. FDA-iRISK–a comparative risk assessment system for evaluating and ranking food-hazard pairs: case studies on microbial hazards. J Food Prot 2013 Mar;76(3):376-85.

Cheng VYS, Arhonditsis GB, Sills DML, Auld H, Shephard MW, Gough WA, et al. Probability of tornado occurrence across Canada. Journal of Climate 2013;26:9415-28.

Hrudey SE, Bull RJ, Cotruvo JA, Paoli G, Wilson M. Drinking water as a proportion of total human exposure to volatile N-nitrosamines. Risk Anal 2013 Dec;33(12):2179-208.

Krishnan K, Carrier R. The use of exposure source allocation factor in the risk assessment of drinking-water contaminants. J Toxicol Environ Health B Crit Rev 2013;16(1):39-51.

Mattison DR. Clinical Pharmacology During Pregnancy. 1st ed. Academic Press; 2013.

Mattison DR. Pharmacokinetics in Real Life: Sex and Gender Differences. Journal of Population Therapeutics & Clinical Pharmacology 2013;20(3):e340-e349.

Rhomberg LR, Goodman JE, Bailey LA, Prueitt RL, Beck NB, Bevan C, et al. A survey of frameworks for best practices in weight-of-evidence analyses. Crit Rev Toxicol 2013 Oct;43(9):753-84.

Xie RH, Guo Y, Krewski D, Mattison D, Nerenberg K, Walker MC, et al. Trends in using beta-blockers and methyldopa for hypertensive disorders during pregnancy in a Canadian population. Eur J Obstet Gynecol Reprod Biol 2013 Dec;171(2):281-5.


Almaskut A, Farrell PJ, Krewski D. Statistical methods for estimating the environmental burden of disease in Canada, with applications to mortality from fine particulate matter. Environmetrics 2012;23(4):329-44.

Krewski D, Turner MC, Lemyre L, Lee JEC. Expert vs. public perception of population health risks in Canada. Journal of Risk Research 2012;15(6):601-25.

Lal PN, Mitchell T, Aldunce P, Auld H, Mechler R, Miyan A, et al. National systems for managing the risks from climate extremes and disasters. In: Field CB, Barros V, Stocker TF, Qin D, Dokken DJ, Ebi KL, et al., editors. Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation.Cambridge, UK and New York, NY, USA: Cambridge University Press; 2012. p. 339-92.

Turner MC, Krewski D, Chen Y, Pope CA, III, Gapstur SM, Thun MJ. Radon and COPD mortality in the American Cancer Society Cohort. Eur Respir J 2012 May;39(5):1113-9.

Turner MC, Krewski D, Chen Y, Pope CA, III, Gapstur SM, Thun MJ. Radon and nonrespiratory mortality in the American Cancer Society cohort. Am J Epidemiol 2012 Nov 1;176(9):808-14.


Guo C, Hoekstra RM, Schroeder CM, Pires SM, Ong KL, Hartnett E, et al. Application of Bayesian techniques to model the burden of human salmonellosis attributable to U.S. food commodities at the point of processing: adaptation of a Danish model. Foodborne Pathog Dis 2011 Apr;8(4):509-16.

Sand S, Portier CJ, Krewski D. A signal-to-noise crossover dose as the point of departure for health risk assessment. Environ Health Perspect 2011 Dec;119(12):1766-74.

Steenhof P, Sparling E. The Role of Codes, Standards, and Related Instruments in Facilitating Adaptation to Climate Change. In: Ford JD, Berrang-Ford L, editors. Climate Change Adaptation in Developed Nations. Springer Netherlands; 2011. p. 243-54.

Turner MC, Krewski D, Chen Y, Pope CA, III, Gapstur S, Thun MJ. Radon and lung cancer in the American Cancer Society cohort. Cancer Epidemiol Biomarkers Prev 2011 Mar;20(3):438-48.


An L, Fung KY, Krewski D. Mining pharmacovigilance data using Bayesian logistic regression with James-Stein type shrinkage estimation. J Biopharm Stat 2010 Sep;20(5):998-1012.

Debia M, Krishnan K. Quantitative property-property relationships for computing occupational exposure limits and vapour hazard ratios of organic solvents. SAR QSAR Environ Res 2010 Oct;21(7-8):583-601.

Shatkin JA, Abbott LC, Bradley AE, Canady RA, Guidotti T, Kulinowski KM, et al. Nano risk analysis: advancing the science for nanomaterials risk management. Risk Anal 2010 Nov;30(11):1680-7.

Turner MC, Wigle DT, Krewski D. Residential pesticides and childhood leukemia: a systematic review and meta-analysis. Environ Health Perspect 2010 Jan;118(1):33-41.

Williams MS, Ebel ED, Golden NJ, Berrang ME, Bailey JS, Hartnett E. Estimating removal rates of bacteria from poultry carcasses using two whole-carcass rinse volumes. Int J Food Microbiol 2010 May 15;139(3):140-6.

Wilson MA, Krewski D, Tyshenko MG. Bovine spongiform encephalopathy risk management in Australia and New Zealand. International Journal of Risk Assessment and Management 2010;14(1-2):17-31.

Wilson MA, Herrera A, Krewski D, Tyshenko MG. Bovine spongiform encephalopathy risk management in Latin America: Costa Rica as a representative country for risk management and policy. International Journal of Risk Assessment and Management 2010;14(1-2):50-60.

Wilson MA, Darshan S, Krewski D, Tyshenko MG. Risk management strategies for bovine spongiform encephalopathy in South America. International Journal of Risk Assessment and Management 2010;14(3-4):254-72.